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Lipid-associated macrophages in the normal mouse aorta and five mouse models of aortic dissection (A) Representative immunofluorescence images of aortic sections from control mice and five AD mouse models. Scale bars, 200 μm (low magnification) and 20 μm (high magnification). (B) Quantification of <t>FABP5</t> + CD68 + macrophages normalized to total CD68 + macrophages across different models. Data are presented as mean ± SD. Statistical significance was assessed using one-way ANOVA with multiple comparisons. ∗∗∗∗ p < 0.0001 and ∗∗ p < 0.01; ns, not significant.
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Lipid-associated macrophages in the normal mouse aorta and five mouse models of aortic dissection (A) Representative immunofluorescence images of aortic sections from control mice and five AD mouse models. Scale bars, 200 μm (low magnification) and 20 μm (high magnification). (B) Quantification of <t>FABP5</t> + CD68 + macrophages normalized to total CD68 + macrophages across different models. Data are presented as mean ± SD. Statistical significance was assessed using one-way ANOVA with multiple comparisons. ∗∗∗∗ p < 0.0001 and ∗∗ p < 0.01; ns, not significant.
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Lipid-associated macrophages in the normal mouse aorta and five mouse models of aortic dissection (A) Representative immunofluorescence images of aortic sections from control mice and five AD mouse models. Scale bars, 200 μm (low magnification) and 20 μm (high magnification). (B) Quantification of <t>FABP5</t> + CD68 + macrophages normalized to total CD68 + macrophages across different models. Data are presented as mean ± SD. Statistical significance was assessed using one-way ANOVA with multiple comparisons. ∗∗∗∗ p < 0.0001 and ∗∗ p < 0.01; ns, not significant.
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Lipid-associated macrophages in the normal mouse aorta and five mouse models of aortic dissection (A) Representative immunofluorescence images of aortic sections from control mice and five AD mouse models. Scale bars, 200 μm (low magnification) and 20 μm (high magnification). (B) Quantification of <t>FABP5</t> + CD68 + macrophages normalized to total CD68 + macrophages across different models. Data are presented as mean ± SD. Statistical significance was assessed using one-way ANOVA with multiple comparisons. ∗∗∗∗ p < 0.0001 and ∗∗ p < 0.01; ns, not significant.
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Lipid-associated macrophages in the normal mouse aorta and five mouse models of aortic dissection (A) Representative immunofluorescence images of aortic sections from control mice and five AD mouse models. Scale bars, 200 μm (low magnification) and 20 μm (high magnification). (B) Quantification of <t>FABP5</t> + CD68 + macrophages normalized to total CD68 + macrophages across different models. Data are presented as mean ± SD. Statistical significance was assessed using one-way ANOVA with multiple comparisons. ∗∗∗∗ p < 0.0001 and ∗∗ p < 0.01; ns, not significant.
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Lipid-associated macrophages in the normal mouse aorta and five mouse models of aortic dissection (A) Representative immunofluorescence images of aortic sections from control mice and five AD mouse models. Scale bars, 200 μm (low magnification) and 20 μm (high magnification). (B) Quantification of <t>FABP5</t> + CD68 + macrophages normalized to total CD68 + macrophages across different models. Data are presented as mean ± SD. Statistical significance was assessed using one-way ANOVA with multiple comparisons. ∗∗∗∗ p < 0.0001 and ∗∗ p < 0.01; ns, not significant.
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Lipid-associated macrophages in the normal mouse aorta and five mouse models of aortic dissection (A) Representative immunofluorescence images of aortic sections from control mice and five AD mouse models. Scale bars, 200 μm (low magnification) and 20 μm (high magnification). (B) Quantification of <t>FABP5</t> + CD68 + macrophages normalized to total CD68 + macrophages across different models. Data are presented as mean ± SD. Statistical significance was assessed using one-way ANOVA with multiple comparisons. ∗∗∗∗ p < 0.0001 and ∗∗ p < 0.01; ns, not significant.
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Image Search Results


Lipid-associated macrophages in the normal mouse aorta and five mouse models of aortic dissection (A) Representative immunofluorescence images of aortic sections from control mice and five AD mouse models. Scale bars, 200 μm (low magnification) and 20 μm (high magnification). (B) Quantification of FABP5 + CD68 + macrophages normalized to total CD68 + macrophages across different models. Data are presented as mean ± SD. Statistical significance was assessed using one-way ANOVA with multiple comparisons. ∗∗∗∗ p < 0.0001 and ∗∗ p < 0.01; ns, not significant.

Journal: iScience

Article Title: Cross-species scRNA-seq finds ideal mouse models for aortic dissection mechanisms

doi: 10.1016/j.isci.2026.115147

Figure Lengend Snippet: Lipid-associated macrophages in the normal mouse aorta and five mouse models of aortic dissection (A) Representative immunofluorescence images of aortic sections from control mice and five AD mouse models. Scale bars, 200 μm (low magnification) and 20 μm (high magnification). (B) Quantification of FABP5 + CD68 + macrophages normalized to total CD68 + macrophages across different models. Data are presented as mean ± SD. Statistical significance was assessed using one-way ANOVA with multiple comparisons. ∗∗∗∗ p < 0.0001 and ∗∗ p < 0.01; ns, not significant.

Article Snippet: Briefly, arterial sections were dewaxed and hydrated for antigen repair and 3% BSA closure, and then incubated with primary antibodies against α-SMA (1:1000, ab124964, Abcam), CD68 (1:500, GB113109 , Servicebio), FABP5 (1:500, 12348-1-AP, Protein-tech), CD31 (1:2000, ab182981, Abcam), PDGFRA (1:500, ab203491, Abcam) overnight at 4°C.

Techniques: Dissection, Immunofluorescence, Control

Lipid-associated VSMCs in the normal mouse aorta and five mouse models of aortic dissection (A) Representative immunofluorescence images of aortic sections from control mice and five AD mouse models. Scale bars, 200 μm (low magnification) and 20 μm (high magnification). (B) Quantification of FABP5 + VSMCs normalized to total αSMA + VSMCs across different models. Data are presented as mean ± SD. Statistical significance was assessed using one-way ANOVA with multiple comparisons. ∗∗∗∗ p < 0.0001; ns, not significant.

Journal: iScience

Article Title: Cross-species scRNA-seq finds ideal mouse models for aortic dissection mechanisms

doi: 10.1016/j.isci.2026.115147

Figure Lengend Snippet: Lipid-associated VSMCs in the normal mouse aorta and five mouse models of aortic dissection (A) Representative immunofluorescence images of aortic sections from control mice and five AD mouse models. Scale bars, 200 μm (low magnification) and 20 μm (high magnification). (B) Quantification of FABP5 + VSMCs normalized to total αSMA + VSMCs across different models. Data are presented as mean ± SD. Statistical significance was assessed using one-way ANOVA with multiple comparisons. ∗∗∗∗ p < 0.0001; ns, not significant.

Article Snippet: Briefly, arterial sections were dewaxed and hydrated for antigen repair and 3% BSA closure, and then incubated with primary antibodies against α-SMA (1:1000, ab124964, Abcam), CD68 (1:500, GB113109 , Servicebio), FABP5 (1:500, 12348-1-AP, Protein-tech), CD31 (1:2000, ab182981, Abcam), PDGFRA (1:500, ab203491, Abcam) overnight at 4°C.

Techniques: Dissection, Immunofluorescence, Control